Dennis J. Slamon, MD, PhD
University of California, Los Angeles, Los Angeles, California
Acclaimed for having brought about a revolution in breast cancer diagnosis and treatment, Dr. Slamon and colleagues began looking at alterations in genes that regulate growth and discovered that tumors in women with an overexpression of the HER2 protein or an amplification of the HER2 gene were more aggressive. They focused on those tumors, and their research led to the discovery of the monoclonal antibody against HER2, the breast cancer drug trastuzumab (Herceptin), which has been used to treat more than 420,000 women worldwide. Heralded as a major advance in targeted cancer therapies when first introduced, the drug has been included in breast cancer treatment protocols in the United States since receiving FDA approval in 1998.
Dr. Slamon has received dozens of awards and honors for his groundbreaking work, including one that is probably unique among his colleagues: He had a Hollywood movie made of his life and work in 2008: “Living Proof” starred Harry Connick Jr.
2019 Lasker-Debakey Clinical Medical Research Award2019 Sjöberg Prize, The Sjöberg Foundation, Lysekil, Sweden2017 Brinker Award for Scientific Distinction in Clinical Research, Susan G. Komen2008 Daniel Nathans’ Memorial Award, Van Andel Research Institute 2007 Gairdner Foundation International Award 2007 Distinguished Medical Service Award, Friends of the National Library of Medicine 2007 Warren Alpert Foundation Scientific Prize, Harvard Medical School 2006 Breast Cancer Award, European Institute of Oncology 2006 Umberto Veronesi Award for the Future Fight Against Breast Cancer 2006 Donald Ware Waddell Award, Arizona Cancer Center 2006 Lister Award for Translational Medicine, University of Glasgow, Scotland 2006 David A. Karnofsky Memorial Award and Lecture, American Society of Clinical Oncology 2004 Medal of Honor, American Cancer Society 2003 Dorothy P. Landon-AACR Prize for Translational Cancer Research 2002 Jeffrey A. Gottlieb Memorial Award, UT MD Anderson Cancer Center 2001 Brown-Hazen Award for Excellence in the Basic Sciences, Wadsworth Center 2000 Bristol-Myers-Squibb Oncology Millennium Award 1975 MD, PhD, University of Chicago Pritzker School of Medicine