Joseph R. Bertino, MD

Joseph R. Bertino, MD
The Cancer Institute of New Jersey, New Brunswick, New Jersey

Joseph R. Bertino, MD | Class of 2013

An outstanding investigator whose work has had a lasting effect on research, Dr. Bertino and colleagues reported early in his career the observation of gene amplification of DHFR, which opened a new era in drug-resistance research. Later, his work with methotrexate helped explain why some cancer drugs work and some fail. He has done important research on drug resistance in leukemia and soft-tissue sarcomas: Dr. Bertino found that almost a third of leukemia patients clinically resistant to methotrexate had low-level amplification of the dihydrofolate reductase gene. Using sensitive assays, his laboratory showed that impaired transport is a common mechanism of acquired resistance to methotrexate. These and other studies resulted in new analogues and new treatments being introduced in the clinic and brought him international recognition for his role in finding treatments for leukemia and lymphoma. His current studies are focused on finding new drug targets for tumor stem cells in prostate cancer.

Dr. Bertino is a translational researcher who seeks to build bridges between the laboratory and the clinic and an inspirational teacher and collaborator who has guided many of the current leaders in the field of cancer research. He is the founding editor-in-chief of Journal of Clinical Oncology.

Career Highlights

2018  AACR Award for Lifetime Achievement in Cancer Research
2018  Giants of Cancer Care, OncLive┬«, Cranbury, New Jersey
2011  Jeffrey A. Gottlieb Memorial Award, UT MD Anderson Cancer Center
2009  Outstanding Medical Research Scientist Award for Clinical Research, Edward J. Ill Excellence in Medicine Foundation, Inc.
2008  AACR -Joseph H. Burchenal Memorial Award
2008  John Ultman Award for Contributions to Lymphoma Research
2006  Key to the Cure Award, Lymphoma Research Foundation
2004  Freundlich Leadership Award, Lymphoma Research Foundation
1995-1996  President, AACR
1992  David A. Karnofsky Memorial Award, American Society of Clinical Oncology (ASCO)
1990-2002  Chairman, Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Institute for Cancer Research
1986-1990  Professor of Medicine and Pharmacology, Cornell University School of Medicine
1978  AACR-Richard and Hinda Rosenthal Award
1978  Jenaro Haddock Award, University of Puerto Rico
1976-1979  Board of Directors, AACR
1975  President, ASCO
1973-1975  Director, Yale Comprehensive Cancer Center, Yale University School of Medicine
1954  MD, Downstate Medical Center, Brooklyn