Brian J. Druker, MD
Oregon Health & Science University, Portland, Oregon
A recognized leader in the field of anti-cancer drug development, Dr. Druker was instrumental in the development of Gleevec (imatinib), a breakthrough drug that served as the proof of principle for targeted cancer therapies. Dr. Druker developed 4G10, an anti-phosphotyrosine antibody essential to Novartis scientists’ kinase inhibitor drug discovery program. His laboratory performed the critical pre-clinical studies of imatinib, a drug that precisely eliminates cancerous cells fueled by BCR-ABL kinase activity without harming normal cells. Thereafter, Dr. Druker spearheaded the highly successful clinical trials of imatinib for CML, which led to the FDA approval of the drug in record time.
Dr. Druker’s work demonstrated the possibility of transforming cancer into a manageable disease, a concept previously unimagined. Imatinib not only established a new treatment paradigm for cancer, but the hundreds of targeted therapies developed in its wake have significantly impacted the direction of cancer research.
2019 Sjöberg Prize, The Sjöberg Foundation, Lysekil, Sweden2018 Tang Prize in Biopharmaceutical Science, Tang Prize Foundation, Taipei, Taiwan2017 Science of Oncology Award and Lecture, American Society of Clinical Oncology2013 Albany Medical Center Prize in Medicine and Biomedical Research 2013 Taubman Prize for Excellence in Translational Medicine Science 2012 Elected Fellow, American Academy of Arts and Sciences2012 The Japan Prize in Healthcare and Medical Technology2011 Ernest Beutler Prize, American Society of Hematology2011 Stanley J. Korsmeyer Award, American Society for Clinical Investigation2009 Lasker-Debakey Award for Clinical Medical Research2007 Elected Member, National Academy of Sciences, Washington, DC2007 Keio Medical Science Prize2006 Elected Member, American Association of Physicians2003 Elected Member, Institute of Medicine2003 David A. Karnofsky Award, American Society of Clinical Oncology2002 Charles F. Kettering Prize, General Motors Cancer Research Foundation2002 Medal of Honor, American Cancer Society2001 Warren Alpert Foundation Prize, Harvard Medical School2001 AACR-Richard and Hinda Rosenthal Foundation Award1981 MD, University of California School of Medicine, San Diego