AACR-Novocure Tumor Treating Fields Research Fellowship
The AACR-Novocure Tumor Treating Fields Research Fellowship represents a joint effort to promote and support postdoctoral and clinical research fellows to conduct innovative research focused on Tumor Treating Fields (TTFields), which are intermediate frequency, low intensity, alternating electric fields that disrupt cell division in cancer cells. This grant is intended to provide a deeper understanding of the mechanisms of action of this novel anti-cancer treatment modality and to accelerate the development of new treatment strategies to advance therapeutic options for cancer. The research proposed for funding must be focused on the preclinical application of TTFields in cancer and may be basic or translational in nature.
Preshita Desai, PhD
Western University of Health Sciences
Tumor Treating Fields triggered targeting of nanoparticles in cancer
Scientific Statement of Research
In recent years, Tumor Treating Fields (TTFields) has emerged as a promising, non-invasive modality in the treatment of cancer. It is critical to note that although TTFields are relatively safe, their concurrent use with anticancer drugs will continue to offer non-site specific severe drug adverse effects. To address this unmet need, Dr. Desai has proposed a novel approach, Tumor Treating Fields Triggered Targeting of Nanoparticles in Cancer (TTFields-TTONIC), for pancreatic cancer treatment. She aims to develop, optimize, and assess targeted self-assembling nanoparticles capable of releasing anticancer drugs at tumor sites in the presence of TTFields to ensure tumor specificity. With her studies, Dr. Desai proposes to investigate concurrent use of TTFields and TTFields-TTONIC to enhance the overall cancer treatment efficacy with significant reduction in side effects.
Dr. Desai works as a research scientist in Dr. Sunil Prabhu’s lab at the Western University of Health Sciences. She received her Bachelor of Pharmacy (2010), Master of Pharmacy in Pharmaceutics (2012) and PhD (Tech.) in Pharmaceutics (2016) from the Institute of Chemical Technology, India. She received an INSPIRE Fellowship and UKIERI Visiting Fellowship (UK-India) to conduct her doctoral studies. Dr. Desai is a formulation scientist with significant experience in the pharmaceutical and biopharmaceutical sector and specializes in nanotechnology based targeted delivery systems. She is presently pursuing multiple projects on nano-formulation development for cancer treatment and prevention.
Acknowledgement of Support
I am honored to receive the AACR-Novocure Tumor Treating Fields Research Fellowship, which will give me an opportunity to develop Tumor Treating Fields targeted nano-drug delivery systems for the treatment of cancer. This fellowship is a key milestone in my career and will enable me to become an independent scientist.
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