Alan D. D’Andrea, MD
Chief, Division of Genomic Stability and DNA Repair, Harvard Medical School; Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology, Dana-Farber Cancer Institute
Elizabeth M. Swisher, MD
Professor, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology; Medical Director, Breast and Ovarian Cancer Prevention Program, Seattle Cancer Care Alliance
Ovarian cancer is usually diagnosed at an advanced stage, when it is hard to treat and death rates are high. Cancers with certain types of DNA repair defects are responsive to targeted therapies, such as drugs called PARP inhibitors.
The Dream Team brought together internationally renowned experts to focus on developing new therapies that target DNA repair and on expanding the use of drugs called PARP inhibitor to a much larger group of women. In addition, by screening for inherited mutations in genes linked to DNA repair, the team worked to find ways to identify women at higher risk for ovarian cancer. The team has taken a three-pronged approach to its goals:
Progress to Date
The Dream Team has made significant progress in the completion of its scientific aims:
1. Identified new DNA repair biomarkers which will contribute to predicting PARPi sensitivity or resistance. The team deployed these biomarkers, and functional tests for HR and fork stability, in short-term ovarian cancer organoid cultures, suitable for predicting drug response.
2. Analyzed the results of a Phase 2 combination of PARPi plus anti-PD1 antibody.
3. Opened the MAGENTA and WISP programs to develop web-based genetic testing and counselling strategies for ovarian cancer risk, providing access to more women in the community, and test fallopian tube removal as a surgical approach to reduce risk that will avoid forced menopause by preserving a woman's ovaries.
Gini F. Fleming, MD, The University of ChicagoScott H. Kaufmann, MD, PhD, Mayo Clinic, RochesterMaria Jasin, PhD, Memorial Sloan Kettering Cancer CenterKaren H. Lu, MD, MD Anderson Cancer Center
Jamie Crase, ovarian cancer survivor and advocate
Kathleen Gavin, Executive Director, Minnesota Ovarian Cancer Alliance
Sue Friedman, executive director of Facing Our Risk of Cancer Empowered (FORCE)