At the heart of Stand Up To Cancer’s (SU2C’s) research program is the Dream Team approach. A Dream Team is a scientific task force, a collaboration of top researchers at different institutions who come together to develop new and improved approaches to cancer. By pooling their knowledge and their resources and working together for common goals, they can make progress faster and move therapies and treatments from the laboratory to doctors’ offices, where they can benefit patients.
SU2C’s distinctive approach to funding cancer research was specifically designed to eliminate barriers to creativity and collaboration by enabling scientists with different areas of expertise from different institutions across the country and around the world to work together. The approach breaks down the “silos” that in the past have often kept scientists from working together.
The American Association for Cancer Research (AACR) has been the Scientific Partner of SU2C since it was launched in 2008, working closely with a Scientific Advisory Committee headed by Nobel Laureate Phillip A. Sharp of MIT.
The AACR is responsible for administering the Dream Team grants, distributing the funds to the Dream Team leaders’ institutions, following the Dream Teams’ progress, and providing scientific oversight through program management and evaluation of the Dream Teams’ achievements during the funding period.
Here are some details on active Dream Teams:
SU2C Meg Vosburg T-Cell Lymphoma Dream Team: Tailoring CAR-based Immunotherapy Strategies to T-cell LymphomaLeader: Helen Heslop, MD, Baylor College of MedicineCo-leader: Gianpietro Dotti, MD, University of North Carolina Lineberger Comprehensive Cancer CenterTotal funding: $8 million
SU2C Colorectal Cancer Dream Team: Targeting Genomic, Metabolic and Immunological Vulnerabilities of Colorectal CancerLeader: Luis A. Diaz Jr., MD, Memorial Sloan Kettering Cancer CenterCo-leaders: Charles S. Fuchs, MD, MPH, Yale Cancer Center, Lewis C. Cantley, PhD, Weill Cornell Medicine and Zhenghe Wang, PhD, Case Western Reserve UniversityGrant Term: January 2017 - December 2019Total Funding: $12 million
SU2C-Cancer Research UK–Lustgarten Foundation Pancreatic Cancer Dream Team: Reprogramming of Transcriptional Circuitry to Control Pancreatic Cancer
Leader: Daniel D. Von Hoff, MD, FACP, Translational Genomics Research Institute (TGen)Co-leaders: Ronald M. Evans, PhD, Salk Institute for Biological Studies; and Gerard I. Evan, PhD, University of CambridgeGrant Term: January 2016 – December 2018Total Funding: $12 million
SU2C Canada-Canadian Cancer Society Breast Cancer Dream Team Leader: Tak W. Mak, PhD, Princess Margaret Cancer Centre, TorontoCo-leader: Samuel Aparicio, BM, BCh, PhD, University of British ColumbiaGrant Term: January 2016 – December 2019 Total Funding: $9 million CAD
SU2C Canada Cancer Stem Cell Dream Team: Targeting Brain Tumour Stem Cell Epigenetic and Molecular Networks
Leader: Peter B. Dirks, MD, PhD, The Hospital for Sick Children, TorontoCo-leader: Samuel Weiss, PhD, Hotchkiss Brain Institute, CalgaryGrant Term: October 2015 – September 2019 Total Funding: $11.79 million CAD
SU2C-American Cancer Society Lung Cancer Dream Team: Targeting KRAS Mutant Lung Cancers
Leader: Jedd D. Wolchok, MD, PhD, Memorial Sloan Kettering Cancer CenterCo-leader: Alice T. Shaw, MD, PhD, Massachusetts General HospitalCo-leader: Pasi A. Jänne, MD, PhD, Dana-Farber Cancer InstituteGrant Term: August 2015 – July 2018 Total Funding: $20 million
SU2C-Ovarian Cancer Research Fund Alliance-National Ovarian Cancer Coalition Ovarian Cancer Dream Team
Leader: Alan D. D’Andrea, MD, Dana-Farber Cancer InstituteCo-leader: Elizabeth M. Swisher, MD, University of WashingtonGrant Term: July 2015 – June 2018Total Funding: $6 million
SU2C-Dutch Cancer Society Colorectal Cancer Dream Team: Molecular Early Detection of Colorectal Cancer - MEDOCC
Leader: Gerrit A. Meijer, MD, The Netherlands Cancer InstituteCo-leader: Victor E. Velculescu, MD, PhD, Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsGrant Term: April 2015 – March 2018 Total Funding: €6 million
Van Andel Research Institute-SU2C Cancer Epigenetics Dream Team
Leaders: Peter A. Jones, PhD, DSc, Van Andel Research Institute; Stephen B. Baylin, MD, Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsGrant Term: October 2014 – September 2017 Total Funding: $7.5 million
St. Baldrick's Foundation-SU2C Pediatric Cancer Dream Team: Immunogenomics to Create New Therapies for High-Risk Childhood Cancers
Leader: John M. Maris, MD, The Children’s Hospital of Philadelphia Co-leader: Crystal L. Mackall, MD, National Cancer Institute Grant Term: July 2013 – June 2017 Total Funding: $14.5 million
The following teams have completed their projects. Details of their work are available on the Stand Up To Cancer website.
SU2C-Lustgarten Foundation Pancreatic Cancer Dream Team: Transforming Pancreatic Cancer to a Treatable Disease
Leader: Elizabeth M. Jaffee, MD, Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsCo-leader: Robert H. Vonderheide, MD, DPhil, Abramson Cancer Center, University of PennsylvaniaGrant Term: July 2014 – June 2017 Total Funding: $8 million
SU2C-Dutch Cancer Society Tumor Organoids Dream Team: Tumor Organoids: A New Pre-Clinical Model for Drug Sensitivity Analysis
Leader: Hans Clevers, MD, PhD, Hubrecht Institute [Current institution: The Netherlands Cancer Institute] Co-leader: Johannes L. Bos, PhD, University Medical Center (UMC) Utrecht Grant Term: April 2014 – March 2018 Total Funding: €6 million
SU2C-Cancer Research Institute Cancer Immunology Dream Team: Immunologic Checkpoint Blockade and Adoptive Cell Transfer in Cancer Therapy
Leaders: James P. Allison, PhD, The University of Texas MD Anderson Cancer Center ; and Antoni Ribas, MD, PhD, University of California, Los Angeles (UCLA) Co-leaders: Drew M. Pardoll, MD, PhD, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; and Cassian Yee, MD, The University of Texas MD Anderson Cancer Center Grant Term: March 2013 – February 2016 Total Funding: $11 million
SU2C-Prostate Cancer Foundation Prostate Cancer Dream Team: Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer
Leader: Eric J. Small, MD, University of California, San Francisco Co-leader: Owen N. Witte, MD, University of California, Los Angeles Grant Term: January 2013 – December 2015 Total Funding: $10 million
SU2C-Prostate Cancer Foundation Prostate Dream Team: Precision Therapy of Advanced Prostate Cancer
Leader: Arul M. Chinnaiyan, MD, PhD, University of Michigan Co-leader: Charles L. Sawyers, MD, Memorial Sloan¬ Kettering Cancer Center Grant Term: August 2012 – July 2016 Total Funding: $10 million
SU2C-Melanoma Research Alliance Melanoma Dream Team: Personalized Medicine for Patients With BRAF Wild-Type (BRAFwt) Cancer
Leader: Jeffrey M. Trent, PhD, FACMG, The Translational Genomics Research Institute (TGen) Co-leader: Patricia M. LoRusso, DO, Yale Cancer Center [Previously: Karmanos Cancer Institute and Wayne State University School of Medicine]Grant Term: April 2012 – December 2015 Total Funding: $6 million
SU2C Epigenetics Dream Team: Bringing Epigenetic Therapy to the Forefront of Cancer Management
Leader: Stephen B. Baylin, MD, Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsCo-leader: Peter A. Jones, PhD, DSc, University of Southern California [Current Institution: Van Andel Research Institute]Grant Term: December 2009 – January 2015 Total Funding: $10.2 million
SU2C PI3K Dream Team: Targeting the PI3K Pathway in Women's Cancers
Leader: Lewis C. Cantley, PhD, Beth Israel Deaconess Medical Center [Current Institution: Meyer Cancer Center at Weill Cornell Medical College]Co-leader: Gordon B. Mills, MD, PhD, The University of Texas MD Anderson Cancer Center Grant Term: November 2009 – October 2013 Total Funding: $14.9 million
SU2C Circulating Tumor Cell Dream Team: Bioengineering and Clinical Applications of Circulating Tumor Cell Chip
Leader: Daniel A. Haber, MD, PhD, Massachusetts General Hospital Cancer Center Co-leader: Mehmet Toner, PhD, Massachusetts General Hospital Grant Term: December 2009 – November 2013 Total Funding: $15 million
SU2C Pancreatic Cancer Dream Team: Cutting off the Fuel Supply: A New Approach to the Treatment of Pancreatic Cancer
Leader: Craig B. Thompson, MD, Abramson Cancer Center, University of Pennsylvania [Current Institution: Memorial Sloan Kettering Cancer Center]Leader: Daniel D. Von Hoff, MD, FACP, The Translational Genomics Research Institute (TGen) Grant Term: December 2009 – May 2015 Total Funding: $22.25 million
SU2C Breast Cancer Dream Team: An Integrated Approach to Targeting Breast Cancer Molecular Subtypes and Their Resistance Phenotypes
Leader: Dennis J. Slamon, MD, PhD, UCLA's Jonsson Comprehensive Cancer Center Leader: Joe W. Gray, PhD, Lawrence Berkeley National Laboratory [Current institution: Oregon Health and Science University] Grant Term: October 2009 – September 2013 Total Funding: $17.5 million
For non-media related SU2C questions, please send an email to SU2C@aacr.org.
Updated: Sept. 18, 2019