Scientists on Science
Andrea Califano, PhD
Professor of Systems Biology (in Biomedical Informatics and the Institute for Cancer Genetics);
Chief, Division of Biomedical Informatics;
Director, Columbia Initiative in Systems Biology;
Director, Center for the Multi-scale Analysis of Genomic Networks;
Associate Director for Bioinformatics, Herbert Irving Comprehensive Cancer Center, Columbia University
Dr. Califano is the Clyde and Helen Wu professor of chemical systems biology in the Department of Systems Biology, Biochemistry and Molecular Biophysics, and Biomedical Informatics at Columbia University Medical Center. He also serves as the founding chair of the Department of Systems Biology, director of the JP Sulzberger Columbia Genome Center, and associate director for bioinformatics of the Herbert Irving Comprehensive Cancer Center. After completing a doctoral thesis in physics at the University of Florence, Italy, Califano worked at the IBM TJ Watson Research Center, where he became involved in computational biology in 1990. In 1997 he became program director of the IBM Computational Biology Center. In 2000 he co-founded First Genetic Trust Inc. to pursue translational genomics research. Finally, he joined Columbia in 2003.
The Califano Lab uses a combination of computational and experimental methodologies to reconstruct the regulatory logic of human cells in genome-wide fashion. He has shown that analysis of this logic can identify master regulator proteins responsible for human disease, including cancer and neurodegenerative syndromes, as well as for normal tissue development. In addition, his lab has developed methods for discovering compounds and compound combination that can inactivate these proteins, thus providing valuable therapeutic strategies. Califano is very active nationally, serving on numerous editorial and scientific advisory boards, including the Board of Scientific Advisors of the National Cancer Institute, St. Jude Children's Hospital, The MIT Koch Cancer Center, Cancer Genetics Inc., and Thermo Fisher Scientific Inc., among others.